Siamois, Goosecoid, and axis

Title: Siamois, Goosecoid, and axis
Category: Science & Technology | Words: 565 | Pages: 2.4 (approximately 235 words/page)

Siamois, Goosecoid, and axis

Axis formation is established very early in the development of vertebrates. Much research has been done in this area, especially with Xenopus, and the consensus is that the dorsal lip plays a key role in establishing the dorsal-ventral and anterior-posterior axes and organizing the develoment of the organism. Pioneering experiments were done by Spemann and Mangold in the 1920's: by transplanting a dorsal lip from one embryo to a point opposite the native dorsal lip …showed first 75 words of 565 total…

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…showed last 75 words of 565 total…as an inhibitor in the organizer and its expression is necessary for axial development. However, the defects caused by VP16-Gsc were rescued via injection of the wnt inhibitor Frzb, suggesting that the actual effect of Gsc is to repress the Wnt factor Xwnt8. Kessler’s earlier research had shown that Gsc is bound and activated by siamois, but she concludes that “whether additional organizer genes are directly regulated by siamois remains to be determined.”

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