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…showed last 75 words of 742 total…had made epistemology, the question of the relationship between mind and world, the starting point of philosophy. By localizing the soul's contact with body in the pineal gland, Descartes had raised the question of the relationship of mind to the brain and nervous system. Yet at the same time, by drawing a radical ontological distinction between body as extended and mind as pure thought, Descartes, in search of certitude, had paradoxically created intellectual chaos.